Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes

Abstract

In order to limit bacterial infections during wound treatment, it is interesting to consider the concept of loadingmedical devices with antibacterial agents. With this in mind, an innovative system with thermosensitive prop-erties was produced: loading a commercially available gauze with a fatty acid eutectic blend based on lauric acid(LA) and myristic acid (MA). This eutectic blend presents a melting point near physiological temperature, whichtogether with its antibacterial properties make an appealing alternative in biomedical applications. At roomtemperature, the properties and the efficacy of the eutectic blend loaded onto gauzes are preserved, whereas atphysiological temperature the eutectic blend undergoes a phase change that facilitates its diffusion from thegauze. The loading of the eutectic blend onto gauzes was performed using two different supercriticalfluidtechnologies, namely, particle from gas saturated solutions (PGSS) and a derived version of rapid expansion ofsupercritical solution (D-RESS). The PGSS led to a heterogeneous dispersion of the eutectic blend in the gauze,whereas the D-RESS process led to the formation of a homogeneous dispersion along the surface of the gauze.Additionally, with D-RESS no phase separation of the eutectic blend occurred and the cytotoxicity was greatlyimproved compared with PGSS without compromising the antibacterial properties of the fatty acid eutecticblend. Hence, the present study highlights the potential use of theflexible D-RESS process to load the fatty acideutectic blend with antibacterial properties onto medical devices in a controllable way. Overall, the effectsproduced by the loaded gauzes suggest the enormous potential of the developed technology in health-relatedareas.

Journal
Materials Science & Engineering C
Volume
99
Pagination
599-610
Publisher
Elsevier
ISSN
0928-4931
URL
https://www.sciencedirect.com/science/article/pii/S0928493118321295
Keywords
Antibacterial, D-RESS, eutectic mixture, fatty acids, PGSS, thermosensitive devices
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
Dez.Zyme
Year of Publication
2019
DOI
10.1016/j.msec.2019.02.012
Date Published
2019-02-04
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