Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Dual delivery of hydrophilic and hydrophobic drugs from chitosan/ diatomaceous earth composite membranes

Abstract

Oral administration of drugs presents important limitations, which are frequently not granted the importance that they really have. For instance, hepatic metabolism means an important drug loss, while some patients have their ability to swell highly compromised (i.e. unconsciousness, cancer…). Sublingual placement of an accurate Pharmaceutical Dosage Form is an attractive alternative. This work explores the use of the β-chitosan membranes, from marine industry residues, composed with marine sediments for dual sublingual drug delivery. As proof of concept, the membranes were loaded with a hydrophilic (gentamicin) and a hydrophobic (dexamethasone) drug. The physico-chemical and morphological characterization indicated the successful incorporated of diatomaceous earth within the chitosan membranes. Drug delivery studies showed the potential of all formulations for the immediate release of hydrophilic drugs, while diatomaceous earth improved the loading and release of the hydrophobic drug. These results highlight the interest of the herein developed membranes for dual drug delivery. 

Journal
Journal of Materials Science: Materials in Medicine
Volume
29
Issue
3
Pagination
21-33
Publisher
Springer
ISSN
1573-4838
URL
https://link.springer.com/article/10.1007/s10856-018-6025-9
Keywords
Chitosan, diatomaceous earth, Hydrophobic drug, Marine materials, membranes
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
NOVOMAR
Year of Publication
2018
DOI
10.1007/s10856-018-6025-9
Date Published
2018-02-02
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