Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Engineered tubular structures based on chitosan for tissue engineering applications

Abstract

The development of versatile tubular structures is a subject of broad interest in tissue engineering applications. Herein, we demonstrate the production of tubular structures based on chitosan through a combination of dipping, freeze-drying and supercritical technology approaches. The combination of these techniques yields versatile tubes with a perfectly defined hollow imprint, which upon chemical cross-linking with genipin acquire enhanced mechanical properties (Young Modulus (E) and ultimate tensile stress (smax)), as well as improved stability in wet conditions. The biological performance reveals that cells remain attached, well-spread and viable on the surface of cross-linked tubes. As so, is envisioned that our methodology opens up new avenues on tissue engineering approaches, where the design of tubular structures with tuned length, diameter and elasticity is required.

Journal
Journal of Biomaterials Applications
Pagination
1-12
Publisher
journals.sagepub
ISSN
08853282
URL
http://journals.sagepub.com/eprint/FZDEhJHScaHJwA35UIII/full
Keywords
biofunctionality, Biomaterials, Biomimetic, Chitosan, Tissue engineering
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
FOOD4CELLS
Year of Publication
2017
DOI
10.1177/0885328217744698
Date Published
2017-11-29
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