Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Fabricated porous silk fibroin particles for pH-responsive drug delivery and targeting of tumor cells

Abstract

To improve the roles of tumor drug, porous silk fibroin particles have been designed as drug carriers. Doxorubicin (DOX) is encapsulated during the fabrication process of the silk fibroin particles to form DOX loaded silk fibroin particles (SFPs-DOX). Folic acid (FA) is covalently grafted to the surface of the silk fibroin particles (FA-SFPs-DOX) as a target group to the folate receptor of tumor cells. The experimental results showed that under the conditions of low pH, high ionic strength and high enzyme concentration, the release of loaded drugs in particles has stimulus response under various conditions. The synthesized silk fibroin particles have good biocompatibility. The specific binding of fibroin particles to folate receptors provides the particles to with target functions to the tumor cells. The job develops potential application of silk fibroin particles as smart drug carriers for the targeted therapy of tumor.

Journal
Journal of Material Sciences
Volume
54
Issue
4
Pagination
3319-3330
Publisher
Springer
ISSN
0022-2461
URL
https://link.springer.com/article/10.1007/s10853-018-3022-9
Keywords
Silk fibroin, pH-responsive, drug delivery, tumor cells
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
FoReCaST
Year of Publication
2018
DOI
10.1007/s10853-018-3022-9
Date Published
2018-10-22
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