Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells

last updated: 2018-11-19
ProjectNORTE45_3Bs :: publications list
TitleGemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells
Publication TypePapers in Scientific Journals
Year of Publication2018
AuthorsOliveira C., Neves N. M., Reis R. L., Tiago S. H., and Martins A.
Abstract

Aim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115–140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35–42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells.

JournalNanomedicine
Date Published2018-09-07
ISSN1743-5889
DOI10.2217/nnm-2018-0004
Keywordsbreast cancer cells, Chitosan, Drug Delivery System, endothelial cells, Fucoidan, gemcitabine, Nanoparticles, Polyelectrolyte complexation
RightsopenAccess
Peer reviewedyes
Statuspublished

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