Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Kefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications

Abstract

A Kefiran-based scaffold was developed using a freeze gelation technique, and its potential use for both drug delivery system and tissue engineering applications were investigated. This scaffold showed, through micro-computed tomography and scanning electron microscopy, high porosity (82.3 ± 4.4%), thick pore walls (13.4 ± 0.7 μm), aerogel form with foam-like structure, and elastic behaviour (δ = 16 ± 0.7º). Moreover, the Kefiran scaffold degradation showed a delayed profile for over 28 days. The developed scaffold allowed a slow and sustained diclofenac release over two weeks, and the human Adipose-derived Stem Cells, cultured onto the Kefiran scaffold, were metabolically active after 72 h. Therefore, our research suggests that Kefiran cryogel could be a potential candidate for drug delivery of controlled bioactive molecules and tissue engineering scaffolding.  
Journal
Materials Today Communications
Pagination
100554
Publisher
Elsevier
ISSN
2352-4928
URL
https://www.sciencedirect.com/science/article/pii/S2352492818303064#abs0015
Keywords
diclofenac, Drug Delivery System, Kefiran cryogels, scaffolds, Tissue engineering
Rights
Closed Access
Peer Reviewed
Yes
Status
published
Project
KOAT
Year of Publication
2019
DOI
10.1016/j.mtcomm.2019.100554
Date Published
2019-06-25
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