Kefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications

last updated: 2019-07-02
ProjectKOAT :: publications list
TitleKefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications
Publication TypePapers in Scientific Journals
Year of Publication2019
AuthorsRadhouani H., Bicho D., Gonçalves C., Maia F. R., Reis R. L., and Oliveira J. M.
EditorsDe Geuser F., Giebeler L., Humphry-Baker S., Martin T., and Miquelard-Garnier G.
Abstract
A Kefiran-based scaffold was developed using a freeze gelation technique, and its potential use for both drug delivery system and tissue engineering applications were investigated. This scaffold showed, through micro-computed tomography and scanning electron microscopy, high porosity (82.3 ± 4.4%), thick pore walls (13.4 ± 0.7 μm), aerogel form with foam-like structure, and elastic behaviour (δ = 16 ± 0.7º). Moreover, the Kefiran scaffold degradation showed a delayed profile for over 28 days. The developed scaffold allowed a slow and sustained diclofenac release over two weeks, and the human Adipose-derived Stem Cells, cultured onto the Kefiran scaffold, were metabolically active after 72 h. Therefore, our research suggests that Kefiran cryogel could be a potential candidate for drug delivery of controlled bioactive molecules and tissue engineering scaffolding.
 
JournalMaterials Today Communications
Date Published2019-06-25
PublisherElsevier
ISSN2352-4928
DOI10.1016/j.mtcomm.2019.100554
URLhttps://www.sciencedirect.com/science/article/pii/S2352492818303064#abs0015
Keywordsdiclofenac, Drug Delivery System, Kefiran cryogels, scaffolds, Tissue engineering
RightsclosedAccess
Peer reviewedyes
Statuspublished

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