Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Melt Processing of Chitosan-Based Fibers and Fiber-Mesh Scaffolds for the Engineering of Connective Tissues

Abstract

We report the production of chitosan-based fibers and chitosan fiber-mesh structures by melt processing (solvent-free) to be used as tissue-engineering scaffolds. The melt-based approach used to produce the scaffolds does not change their main characteristics, including the surface roughness and microporosity. The porosity, pore size, interconnectivity and mechanical performance of the scaffolds are all within the range required for various tissue-engineering applications. Biological assessments are performed in direct-contact assays. Cells are able to colonize the scaffold, including the inner porous structure. The cells show high indices of viability in all of the scaffold types.

Journal
Macromolecular Bioscience
Edition
10
Issue
12
Pagination
1495–1504
Publisher
WILEY-VCH Verlag GmbH & Co
ISSN
1616-5195
Keywords
Chitosan, Engineering of Connective Tissues, Fiber-Mesh Scaffolds
Rights
Open Access
Peer Reviewed
Yes
Status
published
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