Micro-CT - A Digital 3D Microstructural Voyage into Scaffolds: A Systematic Review of the Reported Methods and Results

last updated: 2019-06-07
TitleMicro-CT - A Digital 3D Microstructural Voyage into Scaffolds: A Systematic Review of the Reported Methods and Results
Publication TypeReview Paper
Year of Publication2018
AuthorsCengiz I. F., Dr. Oliveira J. M., and Reis R. L.
Abstract Text

Background: Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Micro-computed tomography (micro-CT) provides a powerful platform to analyze, visualize, and explore any portion of interest in the scaffold in a 3D fashion without cutting or destroying it with the benefit of almost no sample preparation need. Main body: This review highlights the relationship between the scaffold microstructure and cell behavior, and provides the basics of the micro-CT method. In this work, we also analyzed the original papers that were published in 2016 through a systematic search to address the need for specific improvements in the methods section of the papers including the amount of provided information from the obtained results.

JournalBiomaterials Research
Date Published2018-09-26
ISSN2055-7124
DOI10.1186/s40824-018-0136-8
KeywordsMicrostructure, Mineral density, scaffolds, Systematic review, Tissue engineering
RightsopenAccess
Peer reviewedyes
Statuspublished

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