Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles

last updated: 2019-01-02
ProjectINCIPIT :: publications list
TitleMinimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles
Publication TypePapers in Scientific Journals
Year of Publication2018
AuthorsBrito A., Abul-Haija Y. M., Soares da Costa D., Novoa-Carballal R., Reis R. L., Ulijn R. V., Pires R. A., and Pashkuleva I.
Abstract

We report the co-assembly of aromatic carbohydrate and dipeptide amphiphiles under physiological

conditions as a strategy to generate minimalistic proteoglycan mimics. The resulting nanofibers present

a structural, fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) core and a functional carbohydrate

(Fmoc-glucosamine-6-sulfate or -phosphate) shell. The size, degree of bundling and mechanical

properties of the assembled structures depend on the chemical nature of the carbohydrate amphiphile

used. In cell culture medium, these nanofibers can further organize into supramolecular hydrogels. We

demonstrate that, similar to proteoglycans, the assembled gels prolong the stability of growth factors

and preserve the viability of cultured cells. Our results demonstrate that this approach can be applied to

the design of extracellular matrix (ECM) substitutes for future regenerative therapies.

JournalChemical Science
Date Published2018-12-21
PublisherRoyal Society of Chemistry
ISSN2041-6520
DOI 10.1039/c8sc04361b
URLhttps://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc04361b
Keywordsco-assembly, proteoglycans, self-assembly, supramolecular gels, supramolecular systems
RightsopenAccess
Peer reviewedyes
Statuspublished

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