Oxidized Cashew Gum Scaffolds for Tissue Engineering

last updated: 2019-03-13
TitleOxidized Cashew Gum Scaffolds for Tissue Engineering
Publication TypePapers in Scientific Journals
Year of Publication2019
AuthorsMaciel J. S., Azevedo S., Correia C. R., Costa A. M. S., Costa R. R., Magalhães F. A., Monteiro A. A. S., Costa J. F. G., De Paula R. C. M., Feitosa J. P. A., and Mano J. F.
Abstract

In the last few years, several strategies have been proposed to fabricate scaffolds for tissue engineering (TE) applications; however, they are based on harsh and time‐consuming techniques. The choice for natural polymers such as cashew gum (CG) allows to circumvent the demands of biocompatibility and degradability of TE systems. In this work, CG, a polysaccharide derived from Anacardium occidentale trees, is functionalized with aldehyde groups through periodate oxidation. The resultant oxidized cashew gum (CGO) is mixed with gelatin (GE) to yield a covalently crosslinked hydrogel. CGO/GE sponges are obtained by employing a freeze‐drying methodology to the previously obtained hydrogels. The mechanical properties, swelling ability, and porosity of the GE/CGO sponges are tuned by using CGO with different degrees of oxidation. The resultant sponges can maintain high levels of water absorption and recover their initial mechanical properties after cyclic compression. Moreover, these porous and mechanically robust devices can support the adhesion and proliferation of cells, which can envision their application for the regeneration of soft tissues.

JournalMacromolecular Materials And Engineering
Volume304
Issue3
Pagination1800574
Date Published2019-01-09
PublisherWiley
ISSN1439-2054
DOI10.1002/mame.201800574
URLhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mame.201800574
KeywordsCashew gum, Gelatin, Natural materials
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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