A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering

last updated: 2020-01-03
ProjectNORTE45_3Bs - RL1 :: publications list
TitleA Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering
Publication TypeReview Paper
Year of Publication2019
AuthorsCalejo I., Costa-Almeida R., Reis R. L., and Gomes M. E.
Abstract Text

Musculoskeletal diseases are increasing the prevalence of physical disability worldwide. Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue transitions, allowing for body movements. Owing to their unique compositional and structural gradients, injuries challenge the native interfaces and tissue regeneration is unlikely to occur. Tissue engineering strategies are emerging to emulate the physiological environment of soft-to-hard tissue interfaces. Advances in biomaterial design enable control over biophysical parameters, but biomaterials alone are not sufficient to provide adequate support and guide transplanted cells. Therefore, biological, biophysical, and biochemical tools can be integrated into a multifactorial toolbox, steering prospective advances toward engineering clinically relevant soft-to-hard tissue interfaces.

JournalTrends in Biotechnology
Volume38
Issue1
Pagination83-98
Date Published2019-07-15
ISSN0167-7799
DOI10.1016/j.tibtech.2019.06.003
URLhttps://www.sciencedirect.com/science/article/pii/S0167779919301520
Keywordsbiomaterial design, Biomimetics, gradients, multitissue transitions, regenerative medicine, stem cell differentiation
RightsopenAccess
Peer reviewedyes
Statuspublished

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