Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL‐1β‐Conditioned Environment

last updated: 2020-09-04
ProjectMagTT :: publications list
TitlePulsed Electromagnetic Field Modulates Tendon Cells Response in IL‐1β‐Conditioned Environment
Publication TypePapers in Scientific Journals
Year of Publication2020
AuthorsVinhas A., Rodrigues M. T., Gonçalves A. I., Reis R. L., and Gomes M. E.
Abstract

Strategies aiming at controlling and modulating inflammatory cues may offer therapeutic solutions for improving tendon regeneration. This study aims to investigate the modulatory effect of pulsed electromagnetic field (PEMF) on the inflammatory profile of human tendonderived cells (hTDCs) after supplementation with interleukin1β (IL1β). IL1β was used to artificially induce in-flammatory cues associated with injured tendon environments. The PEMF effect was investigated varying the frequency (5 or 17 Hz), intensity (1.5, 4, or 5 mT), and dutycycle (10% or 50%) parameters to which IL1βtreated hTDCs were exposed to. A PEMF actuation with 4 mT, 5 Hz and a 50% duty cycle decreased the production of IL6 and tumor necrosis factorα (TNFα), as well as the expression of TNFαIL6IL8COX2MMP1MMP2, and MMP3, while IL4IL10, and TIMPexpression increased. These results suggest that PEMF stimulation can modulate hTDCs response in an inflammatory environment holding therapeutic potential for tendon regenerative strategies.

JournalJournal Of Orthopaedic Research
Volume38
Issue1
Pagination160-172
Date Published2020-08-28
PublisherWiley Periodicals, Inc.
ISSN0736-0266
DOI10.1002/jor.24538
URLhttps://doi.org/10.1002/jor.24538
Keywordscytokines, human tendon‐derived cells, IL‐1β, Inflammation, Pulsed electromagnetic field
RightsopenAccess
Peer reviewedno
Statuspublished

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