Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

REMOTE ACTIVATION OF ACTIVIN A TYPE II RECEPTOR VIA MAGNETIC NANOPARTICLES FOR TENDON REGENERATION STRATEGIES

Abstract

Tendon injuries are a worldwide problem affecting several age groups and stem cell based therapies hold potential for tendon strategies guiding tendon regeneration.

Tendons rely on mechano-sensing mechanisms that regulate homeostasis and influence regeneration. The mechanosensitive receptors available in cell membranes sense the external stimuli and initiate mechanotransduction processes. Activins are members of the TGF-β superfamily which participate in several tendon biological processes. It is envisioned that the activation of the activin receptor, trigger downstream Smad2/3 pathway thus regulating the transcription of tenogenic genes driving stem cell differentiation.

Journal
Orthopaedic Proceedings
Volume
100-B
Issue
S4
Publisher
The British Editorial Society of Bone & Joint Surgery
ISSN
2049-4416
URL
https://online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.2018.4.072
Keywords
Activin receptor type IIA, TGF-β/Smad2/3 signaling pathway
Rights
Open Access
Peer Reviewed
Yes
Status
published
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