Biomaterials, Biodegradables and Biomimetics Research Group

Comunication - Oral

Remotely activation of Activin A type II receptor via magnetic nanoparticles for tendon regeneration strategies

Abstract

Tendon injuries are a worldwide problem affecting several age groups and stem cell based therapies hold potential for tendon strategies guiding tendon regeneration.

Tendons rely on mechano-sensing mechanisms that regulate homeostasis and influence regeneration. The mechanosensitive receptors available in cell membranes sense the external stimuli and initiate mechanotransduction processes. Activins are members of the TGF-β superfamily which participate in several tendon biological processes. It is envisioned that the activation of the activin receptor, trigger downstream Smad2/3 pathway thus regulating the transcription of tenogenic genes driving stem cell differentiation. 

Journal
25th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS)
Keywords
Magnetic nanoparticles, mechanotransduction, Tendon
Rights
Open Access
Peer Reviewed
Yes
Status
published
Project
NORTE45_3Bs - RL1
Year of Publication
2017
Date Published
2017-09-25
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