Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Silk fibroin/hydroxyapatite composites for bone tissue engineering

Abstract

Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has
attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of
elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity has limited applications for SF in the orthopedic arena unless suitably functionalized. Hydroxyapatite (HAp) is a well-established bioceramic with biocompatibility and appropriate for constructing orthopedic and dental substitutes. However, HAp ceramics tend to be brittle which can restrict applications in the repair of load-bearing tissues such as bones. Therefore, blending SF and HAp combines the useful properties of both materials as bone constructs for tissue engineering, the subject of this review.

Journal
Biotechnology Advances
Volume
36
Pagination
68-91
Publisher
Elsevier
ISSN
0734-9750
Keywords
Bone Tissue Engineering, hydroxyapatite, Scaffold, Silk Fibroin
Rights
Closed Access
Peer Reviewed
Yes
Status
published
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