Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

In vitro and In vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for achilles tendon tissue engineering

Abstract

In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.

Journal
Journal of Industrial and Engineering Chemistry
Volume
76
Pagination
173-180
Publisher
Elsevier
ISSN
1226-086X
URL
https://www.sciencedirect.com/science/article/pii/S1226086X19301236
Keywords
Electrospinning, Gelatin, Highly aligned nanofiber, polycaprolactone, Tendon tissue engineering applications
Rights
Open Access
Peer Reviewed
Yes
Status
published
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