Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Ultrasound-assisted biosynthesis of novel methotrexate-conjugates

Abstract

New methotrexate-acylglycerols and methotrexate-cyclodextrins (α, β and γ-CD) conjugates were obtained via esterification or transesterification reactions. All reactions were catalysed by esterases namely immobilized Lipase from Candida antarctica B and Lipase from Thermomyces lanuginosus. The use of ultrasound to assist the reactions revealed to be a key factor to obtain high conversion yields on both MTX conjugates. Transesterification reactions including long chain triacylglycerols were only successful when ultrasound was applied. In cyclodextrins esterification a higher number of MTX molecules was also linked to cyclodextrins when ultrasound was used. All the conjugates were characterized by MALDI-TOF and NMR spectroscopy.

Journal
Ultrasonics Sonochemistry
Volume
48
Pagination
51-56
Publisher
Elsevier
ISSN
1350-4177
URL
https://www.sciencedirect.com/science/article/pii/S1350417718302682?via%3Dihub
Keywords
Biosynthesis, cyclodextrins, Lipases, Methotrexate, Triacylglycerols, Ultrasound
Rights
Open Access
Peer Reviewed
Yes
Status
published
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