Biomaterials, Biodegradables and Biomimetics Research Group

Comunications - Poster

Manganese dioxide-based nano/microreactors for long-term MRI imaging and Reactive Oxygen Species scavenging


In a healthy brain, manganese (Mn2+) ions can enter excitable cells and circulate within axons and across synapses. Because these ions can also be used as a contrast agent, Manganese Enhanced Magnetic Imaging (MEMRI) has been used, not only to study Amyotrophic Lateral Sclerosis (ALS), but also to guide intrathecal drug/cell delivery [1]. Mn2+ ions allow long-term T1-weigthed imaging, representing an advantage when compared to other ions. In ALS, motor neuron degeneration occurs and it has been correlated with oxidative stress, which can potentially be a therapeutic target [1]. Previous work [2] has demonstrated the ability of manganese dioxide (MnO2) nanoparticles to scavenge Reactive Oxygen Species (ROS) by breaking down hydrogen peroxide in water, oxygen and Mn2+. As MnO2 nanoparticles present toxicity when administered in high doses, it is our goal to develop MnO2 nano/microreactors, where MnO2 nanoparticles will be blended with a methacrylated gellan-gum (GG-MA) matrix. These nano/microreactors will potentially be used, not only to regulate apoptosis and inflammation in tissues, but also to be delivered and guided by MRI. GG-MA was selected due to its affinity to Mn2+, biocompatibility, biodegradability, easy functionalization and similarity to the extracellular matrix [3]. GG-MA was synthesized according to a previously described protocol [4] and further characterized via FTIR and 1H-NMR. A comparison between synthetized and commercially bought MnO2 nanoparticles will also be performed. Nano/microreactors will be evaluated regarding their rheology, stability, permeability and morphology. Their effect on cell viability and ability to scavenge ROS will also be evaluated.

TERMSTEM 2019 Conference
GG-MA, MnO2 nano/microreactors, MRI imaging, ROS scavenging
Open Access
Peer Reviewed
Year of Publication
Date Published
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