BIOreACT proposes a novel system for 3D cell culture that simulates more realistically the human body on the lab bench. The bioreactor proposed is composed by disposable interconnected dual-chambers which are adapted for mono and co-cultures in a 3D matrix or membranes allowing the breakthrough of testing 2 different scenarios (for example drugs) in a more realistic 3D environment. The system can be used as static or dynamic since the dual-chambers are adaptable to a dynamic platform commercialized apart. Moreover, a compressible module can be added to mimic weight pressure. This technology has applications not only in the development of new drugs but also in stem cell and tissue engineering fields. Another example of a possible application relates to robust phenotypic cell-based cancer diagnostics using viable tumor biopsies to assess patient-specific response to available therapeutic agents.