Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation

Abstract

The administration of a drug-loaded implantable hydrogel at the tumor site after surgical resection is a viable approach to prevent the local recurrence or metastasis. Dimyristoyl glycerophosphorylglycerol (DMPG)-based liposomes were developed for inducing the rapid gelation of silk fibroin (SF) and delivering an anticancer drug, curcumin. Curcumin was loaded in the liposomes and the stability of curcumin was enhanced. The gelation time of liposome-induced SF hydrogels ranged from 3 min to more than 6 h. The biological activity of liposome-SFhydrogels was evaluated in vitro using L929 fibroblasts and MDA-MB-231 breast cancer cells. The release of curcumin can inhibit the growth of cancer cells. Both cells cultured on the surface of the hydrogels loaded with curcumin displayed low cell survival due to the combination of low cell attachment and cytotoxicity of curcumin. Liposome-SF hydrogels show potential as a sealant administered at the tumor site to eliminate residual cancer cells after tumor removal.

Journal
International Journal of Pharmaceutics
Volume
589
Pagination
119844
Publisher
Elsevier
ISSN
0378-5173
URL
https://www.sciencedirect.com/science/article/pii/S0378517320308292
Keywords
Anticancer, Curcumin, hydrogel, Liposome, Silk Fibroin
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
REMIX
Year of Publication
2020
DOI
10.1016/j.ijpharm.2020.119844
Date Published
2020-11-15
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